Lee M. Humans have evolved to avoid starvation rather than obesity, and we defend our body mass through an elaborate system involving the brain, the gut, fat cells, and a network of hormones and neurotransmitters, only a fraction of which have been identified. Obesity, Kaplan said, which represents dysfunction of this system, is likely not one disease but dozens.
Obesity is potentially, in part, a neurological disease. Jeffrey Flier , an endocrinologist and dean of Harvard Medical School, has shown, like others, that repeatedly eating more calories than you burn can damage the hypothalamus, an area of the brain involved in eating and satiety. Louis J. The response is to try to store more fat.
But this message has not found its way into society, where obese people are still often considered self-indulgent and lazy, and face widespread discrimination. Bray points to the work of Adam Drewnowski at the University of Washington, who has shown that obesity is, disproportionately, a disease of poverty. Because of this association, many erroneously see obesity as more of a social condition than a medical one, a condition that simply requires people to try harder.
I think that belief permeates a lot of the medical field. Obesity experts with whom I spoke tended to be more optimistic than other physicians about the possibility that obesity can be treated successfully and that the obesity epidemic will be curbed.
They point to exciting new research—for example, the finding that an alteration in gut bacteria , rather than mechanical shrinking of the stomach or intestine, may be what causes weight loss after gastric bypass. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program.
It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach.
In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to phentermine and topiramate. Do not let anyone else take your medication.
Giving or selling phentermine and topiramate to others may harm them and is against the law. Phentermine and topiramate is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Phentermine and Topiramate pronounced as fen'' ter meen toe pyre' a mate. Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow? What should I do if I forget a dose? What side effects can this medication cause? What should I know about storage and disposal of this medication? Brand names of combination products.
Other uses for this medicine. What special precautions should I follow? Before taking phentermine and topiramate, tell your doctor and pharmacist if you are allergic to phentermine Adipex-P, Suprenza ; topiramate Topamax ; sympathomimetic amine medications such as midodrine Orvaten, ProAmatine or phenylephrine in cough and cold medications ; any other medications, or any of the ingredients in phentermine and topiramate capsules.
Ask your pharmacist or check the Medication Guide for a list of the ingredients. Your doctor will probably tell you not to take phentermine and topiramate if you are taking one or more of these medications or have taken one of these medications during the past 2 weeks. Be sure to mention other prescription or nonprescription medications or herbal products for weight loss and any of the following: amitriptyline Elavil ; carbonic anhydrase inhibitors such as acetazolamide Diamox , methazolamide, or zonisamide Zonegran ; diuretics 'water pills' including furosemide Lasix or hydrochlorothiazide HCTZ ; insulin or other medications for diabetes; ipratropium Atrovent ; lithium Lithobid ; medications for anxiety, high blood pressure, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, ulcers, or urinary problems; medications for seizures such as carbamazepine Carbatrol, Equetro, Tegretol , phenytoin Dilantin , or valproic acid Stavzor, Depakene ; pioglitazone Actos, in Actoplus, in Duetact ; sedatives; sleeping pills; and tranquilizers.
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What Happens if I Miss a Dose? A dose taken too late in the evening may cause insomnia. What are the Possible Side Effects of Phentermine? Less serious side effect of Phentermine may include: Feeling restless or hyperactive Headache, dizziness, tremors Sleep problems insomnia Flushing warmth, redness, or tingly feeling Dry mouth Diarrhea or constipation Upset stomach Increased or decreased interest in sex Impotence. Phentermine can impair your thinking or reactions.
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